Located just northwest of the junction of Interstates 81 and 90, the Comfort Inn & Suites Airport is less than five miles from Syracuse Hancock International Airport. Stay and Fly packages are available; contact the hotel directly for more information. Syracuse University, the Rosamond Gifford Zoo at Burnet Park, Onondaga Lake and the Empire Expo Center, home of the New York State Fairgrounds, are close to the hotel.

The nearby Alliance Bank Stadium is home to the Syracuse Chiefs, the minor league baseball affiliate of the Toronto Blue Jays. Syracuse's Oncenter Complex, a multi-venue exhibition, convention and entertainment facility, is just minutes from this Syracuse, NY hotel. A variety of restaurants and cocktail lounges can be found in the surrounding area, including the Atrium Lounge located on the hotel premises.